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KMID : 0616120100410020122
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Korean Journal of Pharmacognosy
2010 Volume.41 No. 2 p.122 ~ p.129
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The Immunostimulatory Activity of The Water-Extract of Korean Mistletoe Fruit to Activate Murine Peritoneal Macrophages
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Lee Jung-Lim
Yoo Young-Choon
Lee Kyung-Bok
Yang Hyo-Seon
Jeon Young-Ha
Song Kyung-Sik
Kim Jong-Bae
Kang Tae-Bong
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Abstract
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Mistletoe (Viscum album) is a common name for many species of semi-parasitic plants which grow on deciduous trees all over the world. In this study, the immunomodulatory activity of the water-extract of Korean mistletoe fruits (KMF-WE), was investigated on murine peritoneal macrophages. The culture supernatants of KMF-WE-stimulated murine peritoneal macrophages showed the increased production of IFN-g, IL-1b and TNF-a, in a dose-dependent manner. KMF-WE also induced chemokine production from murine peritoneal macrophages such as RANTES, MCP-1, MIP-1a and MIP-1b, as well as nitric oxide (NO) production, in a dose-dependent manner. The gel filtration fraction revealed F-1, which is the early-eluted and high molecular weight product, is the major fraction of KMF-WE to activate the murine peritoneal macrophage to induce cytokines, chemokines and NO. The nature of F-1 fraction needs to be examined in detail in further studies to define the regulatory mechanisms of cytokine or chemokine induction by KMF-WE on macrophages. These results suggest that KMF-WE possess a potent immunostimulant activity and can be a promising candidate available for development of immunomodulators.
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KEYWORD
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Viscum album, fruit-water extract, murine peritoneal macrophage, cytokines, chemokines
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